What question did this study set out to answer?

To synthesize advances in molecular targeting, radiochemistry, personalized dosimetry, and artificial intelligence shaping the next generation of precision radiotheranostics.

July 1, 2026BMJ OncologyOpen Access

Future of radiotheranostics

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Authors

AAAkram Al‐IbraheemKing Hussein Cancer Center SMSerin MoghrabiKing Hussein Cancer Center RARaghad Al-HouwariKing Hussein Cancer Center

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Implication

Review highlights advances in targeted radiopharmaceuticals and personalized dosimetry in diverse malignancies, suggesting transformative potential for precision cancer care.

Key Points

To synthesize advances in molecular targeting, radiochemistry, personalized dosimetry, and artificial intelligence shaping the next generation of precision radiotheranostics.
Literature review summarizing the clinical evolution of established agents such as 177Lu-DOTATATE and 177Lu-PSMA-617.
Evaluation of emerging stromal targets, engineered ligand constructs, novel beta- and alpha-emitting radionuclides, and voxel-level computational dosimetry.
Clinical application is shifting from empiric dosing toward evidence-based paradigms while expanding beyond neuroendocrine and prostate tumors to novel biological targets like fibroblast activation protein.
Targeted alpha therapies and next-generation beta emitters demonstrate higher biological effectiveness, offering distinct advantages for small-volume and micrometastatic disease.
Artificial intelligence-driven workflows and individualized quantitative dosimetry provide scalable frameworks to optimize therapeutic indices and personalize treatment planning.

Cite This Study

Al‐Ibraheem et al. (2026) studied this question.

synapsesocial.com/papers/6a6fd807ac440176ef287f62 https://doi.org/10.1136/bmjonc-2026-001073

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Implication

Review highlights advances in targeted radiopharmaceuticals and personalized dosimetry in diverse malignancies, suggesting transformative potential for precision cancer care.

Future of radiotheranostics

Discussion

Member takes

Implication

Key Points

Cite This Study

Future of radiotheranostics

Discussion

Member takes

Implication

Key Points

Cite This Study

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