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February 20, 2012MoleculesOpen Access

Experimental investigations demonstrated cardiac muscle preservation when astaxanthin is administered prior to ischaemia, and limited human studies show attenuation of oxidative stress and inflammation biomarkers with no significant adverse events.

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Why the study?

Does astaxanthin improve oxidative stress, inflammation, and cardiac muscle preservation in cardiovascular disease?

Population

Patients with cardiovascular disease and experimental animal models of cardiac ischaemia-reperfusion

Design

Review

Authors

RFRobert G. FassettJCJeff S. Coombes

Discussion

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Overview

Promising experimental preservation and biomarker effects warrant clinical caution; leaves open efficacy in cardiovascular disease pending randomized human trials.

Structured PICO

Does astaxanthin improve oxidative stress, inflammation, and cardiac muscle preservation in cardiovascular disease?

P
Population
Patients with cardiovascular disease and experimental animal models of cardiac ischaemia-reperfusion
I
Intervention
Astaxanthin
O
Outcome
Oxidative stress and inflammation biomarkers, cardiac muscle preservationsurrogate

Astaxanthin demonstrates promising antioxidant and anti-inflammatory effects in experimental cardiovascular models, highlighting the need for future human clinical trials.

Limitations

  • Limited, short duration and small sample size studies in humans
  • Human clinical cardiovascular studies using astaxanthin therapy have not yet been reported

Cite This Study

Fassett et al. (2012) studied this question.

synapsesocial.com/papers/6a6fd80af44fa9f079dd562ehttps://doi.org/10.3390/molecules17022030
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of astaxanthin supplementation on inflammatory markers, oxidative stress indices, lipid profile, uric acid level, blood pressure, endothelial function, quality of life, and disease symptoms in heart failure subjects2024 · 3 citations
  2. 2Astaxanthin supplementation and cardiometabolic risk factors in overweight and obese adults: a GRADE-assessed systematic review and meta-analysis2026
  3. 3The effect of astaxanthin supplementation on inflammatory markers, lipid profile, and anthropometric indices in patients with heart failure: a randomized controlled trial2026
  4. 4Exploring the Multifunctional Benefits of Astaxanthin in Aging, Oxidative Stress, Immune Dysfunction, Gut and Skin Health2026 · 2 citations
  5. 5The role of astaxanthin in oxidative stress derived diseases2024