Why the study?
Does Snow Mountain virus challenge elicit a cellular and humoral immune response in healthy adults?
Population
15 healthy adult volunteers, average age 31 years (range 21 to 54), 47% male, 73% white, 27% other races.
Design
Cohort, Dose levels were randomized
Follow-up
21 days postchallenge
Authors
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SMV challenge elicits early Th1 and IgG responses in adults; hypothesis-generating for norovirus immunity and requires validation in natural infection cohorts.
Does Snow Mountain virus challenge elicit a cellular and humoral immune response in healthy adults?
Snow Mountain virus challenge in humans elicits a predominantly Th1-driven cellular and humoral immune response that is cross-reactive within its genogroup.
Lindesmith et al. (2005) studied this question.
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