Why the study?
Does intravenous nitroglycerin affect bleeding time and platelet function in patients undergoing coronary bypass grafting?
Does intravenous nitroglycerin affect bleeding time and platelet function in patients undergoing coronary bypass grafting?
Intravenous nitroglycerin prolongs bleeding time in a dose-dependent manner, likely due to vasodilation and increased venous capacitance rather than altered platelet function.
Answers are grounded in this paper and cite their sources.
May warrant NTG dose caution in CABG to limit bleeding time effects; leaves open clinical bleeding impact and requires randomized confirmation.
The effects of intravenous nitroglycerin (NTG) upon the bleeding time, platelet aggregation response, and plasma 6-keto-PGF1α concentration were measured in 17 patients about to undergo coronary bypass grafting. NTG produced a dose-related prolongation of the bleeding time that correlated with the accompanying decrease in systolic blood pressure. Platelet aggregation was not affected and measurements of 6-keto-PGF1α Failed to reveal detectable levels (< 10 pg/ml) either before or after NTG infusion. This suggests that the prolonged bleeding time associated with NTG infusion may be due to vasodilation and increased venous capacitance, rather than altered vascular-platelet interaction.
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Lichtenthal et al. (1985) studied this question.
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