Why the study?
Does nitroglycerin infusion stimulate prostacyclin synthesis and inhibit platelet function in humans?
Population
6 human subjects
Comparison
Nitroglycerin infusion vs Control infusion values
Design
Other
Follow-up
Two 2-hour periods after infusion
Authors
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Nitroglycerin does not stimulate prostacyclin synthesis in this small cohort; leaves open its platelet effects and requires larger validation.
Does nitroglycerin infusion stimulate prostacyclin synthesis and inhibit platelet function in humans?
Nitroglycerin infusion does not appear to stimulate prostacyclin synthesis or consistently inhibit platelet aggregation in humans when measured noninvasively.
Fitzgerald et al. (1984) studied this question.
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