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May 15, 1996Journal of Clinical InvestigationOpen Access

In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia.

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Why the study?

Does targeting iNOS with antisense oligodeoxynucleotides attenuate acute renal failure in rats subjected to renal ischemia?

Population

Rats subjected to renal ischemia

Design

Preclinical

Authors

ENEisei NoiriBioBank JapanTPTatyana PeresleniStony Brook SchoolFMFrederick W. MillerRutgers, The State University of New Jersey

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Implication

Hypothesis-generating for iNOS antisense in rodent ischemic AKI; leaves open translation to human trials.

Structured PICO

Does targeting iNOS with antisense oligodeoxynucleotides attenuate acute renal failure in rats subjected to renal ischemia?

P
Population
Rats subjected to renal ischemia
I
Intervention
Phosphorothioated derivatives of antisense oligodeoxynucleotides targeting a conserved sequence within the open reading frame of the cDNA encoding the inducible NOS (iNOS)
O
Outcome
Attenuation of acute renal failuresurrogate

Selective knock-down of iNOS using antisense oligodeoxynucleotides protects against ischemic acute renal failure in rats, highlighting the cytotoxic role of iNOS-derived NO.

Cite This Study

Noiri et al. (1996) studied this question.

synapsesocial.com/papers/6a6fda47f44fa9f079dd589dhttps://doi.org/10.1172/jci118681
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