Why the study?
Does P2Y1 genotype affect the antiplatelet response to aspirin in healthy Chinese volunteers?
Population
323 nonsmoker, medication-free healthy volunteers from mainland China. A subset of 24 volunteers…
Comparison
Aspirin 100 mg daily oral dose for 7 days vs Comparison among different P2Y1 genotypic groups
Design
Cohort
Follow-up
7 days
Authors
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P2Y1 893CC genotype was associated with attenuated aspirin response in Chinese volunteers; leaves open whether genotyping informs therapy.
Does P2Y1 genotype affect the antiplatelet response to aspirin in healthy Chinese volunteers?
The P2Y1 893CC genotype appears to confer an attenuated antiplatelet effect during aspirin treatment in healthy Chinese volunteers, whereas COX1 and GPIIIa polymorphisms common in Caucasians are rare.
Li et al. (2007) studied this question.
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