July 24, 1991JAMA
A prospective study of aspirin use and primary prevention of cardiovascular disease in women
Why the study?
Does regular aspirin use reduce the incidence of myocardial infarction and other cardiovascular events in women without prior cardiovascular disease?
Population
87,678 US registered nurses aged 34 to 65 years, free of diagnosed coronary heart disease, stroke, and…
Comparison
Aspirin use (one through six aspirin per week) vs No aspirin use
Design
Cohort
Follow-up
6 years
Authors
Discussion
Loading...
Member takes
Implication
Should not yet change practice for primary prevention in women; observational association leaves open need for randomized confirmation.
Structured PICO
Does regular aspirin use reduce the incidence of myocardial infarction and other cardiovascular events in women without prior cardiovascular disease?
P
Population
87,678 US registered nurses aged 34 to 65 years, free of diagnosed coronary heart disease, stroke, and cancer at baseline.
I
Intervention
Aspirin use (one through six aspirin per week)
C
Comparator
No aspirin use
O
Outcome
Incidence of myocardial infarction, stroke, cardiovascular death, and all important vascular eventshard clinical
The use of one to six aspirin per week is associated with a reduced risk of a first myocardial infarction in women.
Limitations
- Observational design requiring a randomized trial for conclusive data
Cite This Study
JoAnn E. Manson (1991) studied this question.