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May 1, 2021MoleculesOpen Access

Choline Chloride–Lactic Acid-Based NADES As an Extraction Medium in a Response Surface Methodology-Optimized Method for the Extraction of Phenolic Compounds from Hazelnut Skin

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Authors

CFChiara FanaliVGValeria GalloSPSusanna Della Posta

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Overview

Optimization study demonstrates enhanced phenolic extraction from hazelnut skin using a deep eutectic solvent, indicating a greener route for valorizing agricultural food byproducts.

Key Points

  • To screen and optimize a green extraction process using natural deep eutectic solvents to recover high-value phenolic compounds from hazelnut skin waste.
  • Screened fifteen deep eutectic solvents based on choline chloride and betaine by quantifying total phenolic content using the Folin–Ciocalteu assay and HPLC-UV/MS.
  • Optimized an ultrasound-assisted solid-liquid extraction (UA-SLE) protocol via response surface methodology (RSM) by modulating water content, temperature, and solid-to-solvent ratio.
  • The optimal extraction system was identified as a 35% aqueous solution of choline chloride and lactic acid at a 1:2 molar ratio, operated at 80 °C with a 1:25 g·mL⁻¹ solid-to-solvent ratio.
  • The optimized green extraction method recovered 39% more phenolic compounds compared to extraction with conventional organic solvent.

Cite This Study

Fanali et al. (2021) studied this question.

synapsesocial.com/papers/6a6fdd6d53da1ffdb5079811https://doi.org/10.3390/molecules26092652
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Natural Deep Eutectic Solvent as Extraction Media for the Main Phenolic Compounds from Olive Oil Processing Wastes2020 · 106 citations
  2. 2Polyphenolic Composition of Hazelnut Skin2011 · 125 citations
  3. 3Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)2018 · 8 citations
  4. 4Thorough Study of Reactivity of Various Compound Classes toward the Folin−Ciocalteu Reagent2010 · 893 citations
  5. 5Novel solvent properties of choline chloride/urea mixturesElectronic supplementary information (ESI) available: spectroscopic data. See http://www.rsc.org/suppdata/cc/b2/b210714g/2002 · 5,674 citations