Altered Sympathetic Nervous Reactivity and Norepinephrine Transporter Expression in Patients With Postural Tachycardia Syndrome
Why the study?
Do sympathetic nervous reactivity and norepinephrine transporter expression differ in patients with POTS compared to healthy controls?
Population
Patients with postural tachycardia syndrome (POTS) and healthy subjects (HS)
Comparison
Head-up tilt to 40 degrees vs Healthy subjects (HS)
Design
Case-control
Authors
Discussion
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Member takes
Implication
Excessive sympathetic reactivity during tilt in POTS may contribute to symptoms; leaves open whether reduced NET expression is causal or compensatory.
Structured PICO
Do sympathetic nervous reactivity and norepinephrine transporter expression differ in patients with POTS compared to healthy controls?
P
Population
Patients with postural tachycardia syndrome (POTS) and healthy subjects (HS)
I
Intervention
Head-up tilt to 40 degrees
C
Comparator
Healthy subjects (HS)
O
Outcome
Sympathetic nervous system responses (heart rate, muscle sympathetic nerve activity, norepinephrine plasma kinetics) and norepinephrine transporter (NET) protein contentsurrogate
Patients with POTS demonstrate decreased norepinephrine transporter protein expression and excessive sympathetic nerve firing during head-up tilt, though whole-body norepinephrine spillover remains unaltered.
Cite This Study
Lambert et al. (2008) studied this question.