Animal study demonstrates that stem cell-conditioned medium reverses skeletal muscle degeneration in rats, suggesting therapeutic potential for drug-induced myopathy.
Myopathies are diseases with a high incidence rate in the entire world because skeletal muscle degeneration gradually impairs patient movement and may even result in death, necessitating the urgent need for an effective cure. This study aims to explore the efficacy of stem cell conditioned medium (SC-CM) supplied by 2 distinct routes (IMIV) to repair injured skeletal muscle in a rat model of statin-induced myopathy..Fifty adult male albino rats were used in this study, and they were equally divided into five groups. the control group, IV conditioned medium treated group in which myopathy was induced then the rats were IV injected with 0.5 ml of SC-CM in tail vein, IM conditioned medium treated group the rats were locally injected with 0.5 ml of SC-CM after induction of myopathy, the untreated myopathy group was left without treatment for 4 weeks. Blood samples and muscular specimens from all groups were collected for biochemical (CK-MM and Myoglobin levels) and histological studies. All measurements were statistically analyzed.The myopathy group showed marked muscle degeneration, with inflammatory cells infiltration. Compared with control group, there was significant decrease in the area% of PAS and the number of myogenin positive cells and significant increase in mean CK-MM and MYO levels and in the area% of collagen and caspase3 positive cells. Four weeks after SC-CM injection (IMIV), there was marked improvement in histological architecture of the skeletal muscle and all measured parameters. The improvement was more obvious in the IV injected group.
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Ibrahim et al. (2022) studied this question.
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