Key result
Mesenchymal stem cell-conditioned medium significantly improved ejection fraction (62.75% vs 46.83%) and modulated inflammatory cytokines compared to MI control at 4 weeks in a rabbit model.
Why the study?
Does mesenchymal stem cell-conditioned medium improve cardiac function and alter cytokine levels in New Zealand White Rabbits with induced myocardial infarction?
Does mesenchymal stem cell-conditioned medium improve cardiac function and alter cytokine levels in New Zealand White Rabbits with induced myocardial infarction?
Mesenchymal stem cell-conditioned medium demonstrates a protective paracrine effect on the infarcted myocardium in a rabbit model, improving cardiac function and modulating cytokine expression.
Answers are grounded in this paper and cite their sources.
Caution against clinical use of MSC-conditioned medium; leaves open translation from rabbit MI models to human trials.
This study examines the protective effects of mesenchymal stem cell-conditioned (CM) medium on heart tissue after induced myocardial infarction (MI). New Zealand White Rabbits were divided: MI, mesenchymal stem cells (MSC) (300 l), CM(300 l) and Control. Echocardiography was applied, and the levels ofIL-6, TGF- and TNF- were analyzed using ELISA. All tests were done 1, 4 and 8 weeks after the surgery. Histological studies were done 8 weeks after surgery. CM group showed a significant improvement in cardiac function. The level of IL-6 increased significantly in all weeks after surgery in CM. While the level of TNF- increased remarkebly in CM group in 4 th week. TGF- decreased significantly in CM group at all the times. Histological findings confirmed the tissue protection effect of CM. In conclusion, our results support the protective role of CM through its paracrine effects on the MI-induced heart.
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Aboutaleb et al. (2016) studied Myocardial infarction (n=28). Mesenchymal stem cell-conditioned medium (CM) vs. Myocardial infarction (MI) control was evaluated on Ejection fraction (EF) at 4 weeks (p=<0.05). Mesenchymal stem cell-conditioned medium significantly improved ejection fraction (62.75% vs 46.83%) and modulated inflammatory cytokines compared to MI control at 4 weeks in a rabbit model.
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