Why the study?
Do cytokines produced by bone marrow mononuclear cells improve cardiac function and protect cardiomyocytes from ischemic injury in a rat model of myocardial infarction?
Population
Isolated adult rat cardiomyocytes in vitro and a rat model of acute myocardial infarction
Comparison
Supernatants of bone marrow mononuclear cells… vs Control blank medium
Design
Preclinical
Authors
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Supports paracrine BM-MNC effects in rat MI; hypothesis-generating for human translation.
Do cytokines produced by bone marrow mononuclear cells improve cardiac function and protect cardiomyocytes from ischemic injury in a rat model of myocardial infarction?
Cytokines secreted by bone marrow mononuclear cells mediate the functional improvement of the infarcted heart by protecting cardiomyocytes and inducing angiogenesis.
Takahashi et al. (2006) studied this question.
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