What question did this study set out to answer?

May 11, 2017Circulation ResearchOpen Access

Peripheral Blood Cytokine Levels After Acute Myocardial Infarction

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Why the study?

Do peripheral blood cytokines predict bone marrow endothelial progenitor cell colony outgrowth and cardiac function after acute myocardial infarction?

Population

87 participants 14 to 21 days after acute myocardial infarction, and healthy donors as reference

Comparison

Measurement of peripheral blood cytokines and in… vs Healthy donors and unblocked cells

Design

Cohort

Follow-up

14 to 21 days post-AMI

Authors

MSMahan ShahrivariSaint Louis University EWElizabeth WiseJohns Hopkins University MRMicheline ResendeChildren's Cancer Center

Discussion

Member takes

Implication

Suggests systemic inflammation may impair bone marrow regenerative capacity after AMI.

Key Points

To determine whether circulating peripheral blood cytokines predict bone marrow endothelial progenitor cell colony outgrowth and cardiac function following acute myocardial infarction.
Analyzed peripheral blood and bone marrow samples collected 14 to 21 days post-infarction from 87 participants alongside healthy donor controls (NCT00684060).
Evaluated correlations between cytokine levels, cell phenotypes, and cardiac function, and tested in vitro progenitor colony outgrowth in healthy bone marrow treated with IL-1β or IL-6 with and without receptor blockers.
Peripheral blood interleukin-6 negatively correlated with bone marrow endothelial colony–forming cell colony maximum (estimate ± SE, −0.13 ± 0.05; P = 0.007).
Exogenous IL-1β and IL-6 produced dose-dependent reductions in healthy bone marrow endothelial colony–forming cell outgrowth (P < 0.05), which was reversed by blocking IL-1R or IL-6R.
Platelet-derived growth factor BB positively correlated with bone marrow colony-forming unit-endothelial colony maximum (estimate ± SE, 0.01 ± 0.002; P < 0.001) and mesenchymal stromal cell colony maximum in bone marrow (0.01 ± 0.002; P = 0.002) and peripheral blood (0.02 ± 0.005; P < 0.001).

Structured PICO

Do peripheral blood cytokines predict bone marrow endothelial progenitor cell colony outgrowth and cardiac function after acute myocardial infarction?

Population

87 participants 14 to 21 days after acute myocardial infarction, and healthy donors as reference

Intervention

Measurement of peripheral blood cytokines and in vitro blocking of IL-1R or IL-6R

Comparator

Healthy donors and unblocked cells

Outcome

Bone marrow endothelial progenitor cell colony outgrowth and post-AMI cardiac functionsurrogate

Increased peripheral blood IL-6 is associated with bone marrow impairment after AMI, which can be reversed in vitro by blocking IL-1 or IL-6 receptors, suggesting a potential therapeutic target to improve regenerative capacity.

Cite This Study

Shahrivari et al. (2017) studied this question.

synapsesocial.com/papers/6a7cf491d925dff0595e0400 https://doi.org/10.1161/circresaha.116.309947

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Peripheral Blood Cytokine Levels After Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Peripheral Blood Cytokine Levels After Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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