Why the study?
Does intramyocardial injection of wild-type BM-MNCs improve left ventricular function after myocardial infarction in mice compared to diluent or IL-10 knock-out BM-MNCs?
Does intramyocardial injection of wild-type BM-MNCs improve left ventricular function after myocardial infarction in mice compared to diluent or IL-10 knock-out BM-MNCs?
Transplanted bone marrow mononuclear cells mediate cardiac protection and improve left ventricular function after myocardial infarction in mice, a process that is at least partially dependent on IL-10 secretion.
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Does not support clinical translation; leaves open IL-10 dependence of BM-MNC effects on post-MI LV function beyond murine models.
Burchfield et al. (2008) studied this question.
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