Why the study?
Does ex vivo knockdown of miR-375 in BMPACs improve cell survival, myocardial repair, and LV function after myocardial infarction in mice?
Does ex vivo knockdown of miR-375 in BMPACs improve cell survival, myocardial repair, and LV function after myocardial infarction in mice?
Knockdown of miR-375 in bone marrow-derived progenitor cells enhances their survival and improves myocardial repair and left ventricular function after myocardial infarction in mice.
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IL-10/miR-375 modulation may boost stem cell survival post-MI; leaves open translation from murine models to clinical use.
Garikipati et al. (2015) studied this question.
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