February 1, 1967Journal of Clinical InvestigationOpen Access

Tissue Lipoprotein Lipase in Normal Individuals and in Individuals with Exogenous Hypertriglyceridemia and the Relationship of this Enzyme to Assimilation of Fat *

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Why the study?

Does lipoprotein lipase activity differ between normal individuals and those with familial exogenous hypertriglyceridemia?

Population

11 subjects (6 healthy subjects and 5 members of a family with familial exogenous hypertriglyceridemia)

Comparison

Measurement of adipose tissue lipoprotein lipase… vs Healthy subjects

Design

Case-control

Authors

WHWilliam R. HarlanSeattle Children's Hospital PWPreston S. WinesettVirginia Commonwealth University Medical Center AWAlbert J. WassermanVirginia Commonwealth University Medical Center

Discussion

Member takes

Implication

Supports LPL deficiency as cause of familial chylomicronemia; extends mechanistic understanding but leaves open diagnostic or therapeutic use.

Structured PICO

Does lipoprotein lipase activity differ between normal individuals and those with familial exogenous hypertriglyceridemia?

Population

11 subjects (6 healthy subjects and 5 members of a family with familial exogenous hypertriglyceridemia)

Intervention

Measurement of adipose tissue lipoprotein lipase activity (LLA) and response to a 104-g fat meal

Comparator

Healthy subjects

Outcome

Lipoprotein lipase activity (LLA) in adipose tissue and serum triglyceride response to a fat mealsurrogate

The study demonstrates the physiological importance of lipoprotein lipase in the removal of chylomicrons and very low-density lipoproteins, clarifying the mechanism of exogenous hypertriglyceridemia.

Cite This Study

Harlan et al. (1967) studied this question.

synapsesocial.com/papers/6a6fdf73f44fa9f079dd5d91 https://doi.org/10.1172/jci105526

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February 1, 1967Journal of Clinical InvestigationOpen Access

Tissue Lipoprotein Lipase in Normal Individuals and in Individuals with Exogenous Hypertriglyceridemia and the Relationship of this Enzyme to Assimilation of Fat *

View Full Paper

Ask AI

Bookmark

Why the study?

Does lipoprotein lipase activity differ between normal individuals and those with familial exogenous hypertriglyceridemia?

Population

11 subjects (6 healthy subjects and 5 members of a family with familial exogenous hypertriglyceridemia)

Comparison

Measurement of adipose tissue lipoprotein lipase… vs Healthy subjects

Design

Case-control

Authors

WHWilliam R. HarlanSeattle Children's Hospital PWPreston S. WinesettVirginia Commonwealth University Medical Center AWAlbert J. WassermanVirginia Commonwealth University Medical Center

Discussion

Member takes

Implication

Supports LPL deficiency as cause of familial chylomicronemia; extends mechanistic understanding but leaves open diagnostic or therapeutic use.

Structured PICO

Does lipoprotein lipase activity differ between normal individuals and those with familial exogenous hypertriglyceridemia?

Population

11 subjects (6 healthy subjects and 5 members of a family with familial exogenous hypertriglyceridemia)

Intervention

Measurement of adipose tissue lipoprotein lipase activity (LLA) and response to a 104-g fat meal

Comparator

Healthy subjects

Outcome

Lipoprotein lipase activity (LLA) in adipose tissue and serum triglyceride response to a fat mealsurrogate

The study demonstrates the physiological importance of lipoprotein lipase in the removal of chylomicrons and very low-density lipoproteins, clarifying the mechanism of exogenous hypertriglyceridemia.

Cite This Study

Harlan et al. (1967) studied this question.

synapsesocial.com/papers/6a6fdf73f44fa9f079dd5d91 https://doi.org/10.1172/jci105526

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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