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Frustrating: A sterically unencumbered aniline base (see picture, left) can be transformed into a bulky Lewis base by converting it into a [2]rotaxane (right). This Lewis base donor, which is surrounded by a protective macrocyclic ring, exhibits the reactivity of a frustrated Lewis pair (e.g. activation of H2(g)) without the need for direct covalent modification to increase its bulk.
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Caputo et al. (2012) studied this question.
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