Egr-1 Activates Basic Fibroblast Growth Factor Transcription

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Structured PICO

Population

Astrocytes (in vitro model)

Intervention

Endothelin-3 (ET-3) treatment and transfection with mitogen-activated protein (MAP) kinase expression vector

Comparator

Atrial natriuretic peptide (ANP) treatment, dominant negative MAPK mutant

Outcome

Transcription of egr-1 and transactivation of basic fibroblast growth factor (bFGF)surrogate

ET-3 stimulates astrocyte proliferation via MAPK-mediated egr-1 transcription and bFGF transactivation, a pathway that is inhibited by ANP.

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Findings remain preclinical; leaves open whether the ET-3/ANP axis modulates human astrocyte proliferation.

Biesiada et al. (1996) studied this question.

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