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March 15, 2005BloodOpen Access

Induction of tolerance to factor VIII inhibitors by gene therapy with immunodominant A2 and C2 domains presented by B cells as Ig fusion proteins

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Authors

TLTiechi LeiPeking UniversityDSDavid W. ScottBC Cancer Agency

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Lei et al. (2005) studied this question.

synapsesocial.com/papers/6a6fe04f31a3df8243282e02https://doi.org/10.1182/blood-2004-11-4274
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms of Tolerance Induction by a Gene-Transferred Peptide-IgG Fusion Protein Expressed in B Lineage Cells2000 · 70 citations
  2. 2Role of CD154 in the secondary immune response: the reduction of pre-existing splenic germinal centers and anti-factor VIII inhibitor titer2000 · 67 citations
  3. 3Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A2001 · 80 citations
  4. 4Reduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitope2004 · 51 citations
  5. 5Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.1992 · 428 citations