May 1, 1976Annals of the New York Academy of Sciences
Experimental Autoimmune Myasthenia Gravis and Myasthenia Gravis: Biochemical and Immunochemical Aspects*
Why the study?
Does the assay of anti-AChR antibodies differentiate myasthenia gravis patients from nonmyasthenics?
Population
Rats immunized with eel acetylcholine receptor protein; sera from patients with myasthenia gravis and…
Comparison
Immunization with eel AChR; assay of anti-AChR… vs Rats immunized with denatured AChR; sera from…
Design
Preclinical
Authors
Discussion
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Implication
Anti-AChR antibody assay may differentiate myasthenia gravis; hypothesis-generating pending prospective validation.
Structured PICO
Does the assay of anti-AChR antibodies differentiate myasthenia gravis patients from nonmyasthenics?
P
Population
Rats immunized with eel acetylcholine receptor protein (AChR); sera from patients with myasthenia gravis and nonmyasthenics.
I
Intervention
Immunization with eel AChR (in rats); assay of anti-AChR antibodies using AChR from human muscle (in humans).
C
Comparator
Rats immunized with denatured AChR; sera from nonmyasthenics.
O
Outcome
Development of myasthenia and humoral antibodies in rats; detection and titer of antibodies to AChR in human sera.surrogate
The assay of antibodies against human muscle AChR is a highly sensitive diagnostic test for myasthenia gravis, with levels 300-fold higher than in nonmyasthenics.
Cite This Study
Lindstrom et al. (1976) studied this question.