Article1 August 1945ATROPHIC ARTHRITIS ASSOCIATED WITH SPLENOMEGALY AND LEUKOPENIAFRANCIS N. HATCH, M.D.FRANCIS N. HATCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-2-201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1924 Felty1reported the cases of five adults who had atrophic arthritis associated with splenomegaly and leukopenia. The age of the patients ranged from 45 to 65 years. Their arthritis was generalized, relatively benign, and of at least two years' duration. All patients had suffered recent, marked weight loss. Each had a palpably enlarged spleen that was firm and non-tender. Three of the five had enlarged axillary, inguinal or epitrochlear lymph nodes, and all had some degree of yellow-brown pigmentation of the skin, chiefly on the exposed surfaces. Four of the patients had a slight microcytic anemia, and their...Bibliography1. FELTY AR: Chronic arthritis in the adult, associated with splenomegaly and leukopenia. A report of five cases of an unusual clinical syndrome, Bull. Johns Hopkins Hosp., 1924, xxxv, 16. Google Scholar2. PORTIS RB: Pathology of chronic arthritis of children (Still's disease), Am. Jr. Dis. Child., 1938, lv, 1000. IMRIE, A. H., and AITKENHEAD, A. C.: Amyloidosis complicating Still's disease, Lancet, 1939, ii, 421. CARROLL, J. H., and NELSON, R. L.: Still's disease with amyloidosis, Arch. Pediat., 1927, xliv, 187. Google Scholar3. BELL ET: Amyloid disease of the kidneys, Am. Jr. Path., 1933, ix, 185. ROSENBLATT, M. B.: Amyloidosis and amyloid nephrosis, Am. Jr. Med. Sci., 1933, clxxxvi, 558. Cabot case record: Case No. 19142, New England Jr. Med., 1933, ccviii, 757. DIXON, H. M.: Renal amyloidosis in relation to renal insufficiency, Am. Jr. Med. Sci., 1934, clxxxvii, 401. HARDGRAVE, M. U. F.: Retention of congo-red in amyloid disease, Arch. Path., 1933, xv, 238. Google Scholar4. SOLOMON WM: Amyloidosis in chronic atrophic arthritis, Ann. Int. Med., 1943, xviii, 846. REIMANN, H. A., and EKLUND, C. M.: Long-continued vaccine therapy as a cause of amyloidosis, Am. Jr. Med. Sci., 1935, cxc, 88. Google Scholar5. COLLINS DH: Neutrophil leukopenia with enlargement of liver and spleen in rheumatoid arthritis: with a note on the leukocytic blood picture in chronic rheumatism, Rep. Chron. Rheumat. Dis., 1937, iii, 49. EATON, E. R.: Chronic arthritis. A report based on the study of the blood cell count in 250 cases, Jr. Am. Inst. Homeop., 1932, xxv, 125. Google Scholar6. CURTISPOLLARD ACHM: Felty's syndrome: its several features including tissue changes, compared with other forms of rheumatoid arthritis, Ann. Int. Med., 1940, xiii, 2265. Google Scholar7. HENCH PS: Discussion, Jr. Am. Med. Assoc., 1933, ci, 2078. IBID.: Chronic arthritis, Nelson Loose-Leaf Living Surgery, 1935, iii, 108. IBID., and others: Present status of the problem of "rheumatism" and arthritis: review of American and English literature for 1934, Ann. Int. Med., 1936, ix, 883. Google Scholar8. CHAUFFARDRAMOND AF: Des adenopathie dans le rhumatisme chronique infectieux, Rev. de méd., 1896, xvi, 345. Google Scholar9. STILL GF: On a form of chronic joint disease in children, Med. Chir. Trans., 1897, lxxx, 48. Google Scholar10. HERRINGHAM WP: Rheumatoid arthritis, Clin. Jr., 1909, xxxiv, 257. Google Scholar11. SINGERLEVY HAHA: Relationship of Felty's and allied syndromes to sepsis lenta, Arch. Int. Med., 1936, lvii, 576. CrossrefGoogle Scholar12. TALKOVBAUERSHORT RHWCL: Rheumatoid arthritis associated with splenomegaly and leukopenia, New England Jr. Med., 1942, ccxxvii, 395. CrossrefGoogle Scholar13. HANRAHANMILLER EMSR: The effect of splenectomy in Felty's syndrome, Jr. Am. Med. Assoc., 1932, xcix, 1247. CrossrefGoogle Scholar14. CRAVEN EB: Splenectomy in chronic arthritis associated with splenomegaly and leukopenia (Felty's syndrome), Jr. Am. Med. Assoc., 1934, cii, 822. Google Scholar15. PRICESCHOENFELD AEJB: Felty's syndrome. Report of a case with complete postmortem findings, Ann. Int. Med., 1934, vii, 1230. LinkGoogle Scholar16. WARD G: Chronic septic splenomegaly, Lancet, 1923, i, 429. CrossrefGoogle Scholar17. REICH C: A case of Felty's syndrome, Med. Rec., 1936, cxliv, 448. Google Scholar18. WILLIAMS RH: Felty's syndrome: report of a case with necropsy findings, Ann. Int. Med., 1936, ix, 1247. Google Scholar19. STEINBROCKERSESIT OMF: Chronic rheumatoid arthritis with granuloma of the spleen and lymph nodes in a patient presenting the clinical picture of Felty's syndrome, New York State Jr. Med., 1940, xl, 1795. Google Scholar20. LOCKIESANESVAUGHAN LMSSL: Chronic arthritis; associated with neutrophil leukopenia, splenomegaly, and hepatomegaly, Am. Jr. Clin. Path., 1942, xii, 372. CrossrefGoogle Scholar21. STEINBERG CL: The value of splenectomy in Felty's syndrome, Ann. Int. Med., 1942, xvii, 26. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 15, 1945.From the Department of Medicine, Stanford University School of Medicine, and the Department of Public Health, City and County of San Francisco. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySonderformen der chronischen PolyarthritisHaematological Changes in Rheumatoid DiseasePsoriasis arthropathica und AmyloidoseClinical and Serologic Observations on 27 Patients with Felty's SyndromeThe variable features of Felty's syndromeFELTY'S SYNDROMELesions of Lymph Nodes in Rheumatoid Disease and in Disseminated LUPUS ErythematosusDie Panmyelophthise und verwandte Zustände der Knochenmarksinsuffizienz 1 August 1945Volume 23, Issue 2Page: 201-220KeywordsAnemiaArthritisLymph nodesPrevention, policy, and public healthSplenomegalyWeight loss ePublished: 1 December 2008 Issue Published: 1 August 1945 PDF downloadLoading ...
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