Felty's Syndrome; Its Several Features, Including Tissue Changes, Compared With Other Forms of Rheumatoid Arthritis

Article1 June 1940FELTY'S SYNDROME; ITS SEVERAL FEATURES, INCLUDING TISSUE CHANGES, COMPARED WITH OTHER FORMS OF RHEUMATOID ARTHRITISA. C. CURTIS, M.D., F.A.C.P., H. M. POLLARD, M.D., F.A.C.P.A. C. CURTIS, M.D., F.A.C.P.Search for more papers by this author, H. M. POLLARD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-12-2265 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1924 Felty1 described a syndrome occurring in five cases characterized by chronic rheumatoid arthritis, splenomegaly, and leukopenia. The syndrome occurred in individuals of middle age; all patients gave a history of marked loss of weight and all were undernourished; the arthritic process was distinctly chronic with an average duration of four and one-half years; the onset was either acute or gradual; and in the extremities occurred a generalized articular aching, which was mild but persistent, and accentuated by an occasional acute exacerbation.In two of the cases the spleens were palpable just below the costal margins, in two others...Bibliography1. FELTY AR: Chronic arthritis in the adult, associated with splenomegaly and leukopenia. A report of 5 cases of an unusual clinical syndrome, Bull. Johns Hopkins Hosp., 1924, xxxv, 16. Google Scholar2. HANRAHANMILLER EMSR: Effect of splenectomy in Felty's syndrome, Jr. Am. Med. Assoc., 1932, xcix, 1247. CrossrefGoogle Scholar3. SINGER HA: The etiology of Felty's and related syndromes, Jr. Am. Med. Assoc., 1933, ci, 2078. Google Scholar4. ALESSANDRINI P: La splénomégalie arthropathisante, Presse méd., 1934, xlii, 1190. Google Scholar5. CRAVEN EB: Splenectomy in chronic arthritis, associated with splenomegaly and leukopenia (Felty's syndrome), Jr. Am. Med. Assoc., 1934, cii, 822. Google Scholar6. PRICESCHOENFELD AEJB: Felty's syndrome. Report of a case with complete postmortem findings, ANN. INT. MED., 1934, vii, 1230. LinkGoogle Scholar7. FITZ R: Case of Felty's syndrome, Med. Clin. N. Am., 1935, xviii, 1062. Google Scholar8. SINGERLEVY HAHA: Relationship of Felty's and allied syndromes to sepsis lenta, Arch. Int. Med., 1936, lvii, 576. CrossrefGoogle Scholar9. WILLIAMS RH: Felty's syndrome: Report of a case with necropsy findings, ANN. INT. MED., 1936, ix, 1247. Google Scholar10. REICH C: A case of Felty's syndrome, Med. Rec., 1936, cxliv, 448. Google Scholar11. HENCH PF: Acute and chronic arthritis, Nelson Loose-Leaf Living Surgery, 1935, iii, 104. Google Scholar12. CHAUFFARDRAMOND AF: Des adénopathie dans le rhumatisme chronique infectieux, Rev. de méd., 1896, xvi, 345. Google Scholar13. HERRINGHAM WP: Rheumatoid arthritis, Clin. Jr., 1909, xxxiv, 257. Google Scholar14. STILL GF: On a form of chronic joint disease in children, Med. Chir. Trans., 1897, lxxx, 48. Google Scholar15. GIFFIN HZ: Diseases of the spleen, Oxford Med., 1929, iv, Part 1, 76. Google Scholar16. WARD G: Chronic septic splenomegaly, Lancet, 1923, i, 429. CrossrefGoogle Scholar17. MCCRAE T: Arthritis deformans. The report of one hundred ten cases from the Johns Hopkins Hospital, Jr. Am. Med. Assoc., 1904, xlii, 1. CrossrefGoogle Scholar18. HENCH PS: Discussion, Jr. Am. Med. Assoc., 1933 ci, 2078. Google Scholar19. DAWSON MH: Chronic arthritis, Nelson Loose-Leaf Living Medicine, 1935, v, 605. Google Scholar20. EATON ER: Chronic arthritis. A report based on the study of the blood cell count in 250 cases, Jr. Am. Inst. Homeop., 1932, xxv, 125. Google Scholar21. HENCH PS: Present status of problem of "rheumatism" and arthritis; review of American and English literature for 1934, ANN. INT. MED., 1936, ix, 883. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication December 7, 1938.From the Department of Internal Medicine, Medical School, University of Michigan. 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