Why the study?
Does the extent of histological fibrosis correlate with the severity of left ventricular dysfunction in patients with coronary artery disease?
Does the extent of histological fibrosis correlate with the severity of left ventricular dysfunction in patients with coronary artery disease?
Severe decreases in ejection fraction and elevations in left ventricular end diastolic pressure in coronary artery disease may be driven by active ischemia rather than irreversible fibrosis.
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Active ischemia may drive severe LV impairment in CAD beyond fibrosis; leaves open whether fibrosis extent predicts outcomes or guides therapy.
Baltaxe et al. (1974) studied this question.
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