November 26, 2014Pancreas
The ACE2-Angiotensin-(1–7)-Mas Axis Protects Against Pancreatic Cell Damage in Cell Culture
Why the study?
Does Angiotensin-(1-7) treatment reduce pancreatic cell damage in a cell culture model of acute pancreatitis?
Population
AR42J cells stimulated with 10 nmol/L cerulein to simulate acute pancreatitis
Comparison
Angiotensin-(1-7) treatment vs Control group
Design
Preclinical
Follow-up
6 hours
Authors
Discussion
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Member takes
Implication
Supports further preclinical testing of Ang-(1-7) in pancreatitis; leaves open translation beyond this cell culture model.
Structured PICO
Does Angiotensin-(1-7) treatment reduce pancreatic cell damage in a cell culture model of acute pancreatitis?
P
Population
AR42J cells stimulated with 10 nmol/L cerulein to simulate acute pancreatitis
I
Intervention
Angiotensin-(1-7) treatment
C
Comparator
Control group
O
Outcome
Pancreatic cell damage and inflammatory markers (IL-6, IL-8, IL-10)surrogate
The ACE2-angiotensin-(1-7)-Mas axis demonstrates protective, anti-inflammatory effects in a cell culture model of acute pancreatitis.
Cite This Study
Wang et al. (2014) studied this question.