Choosing the Best Oral Diabetic Agents in T2 Diabetes Mellitus-Physicians Challenge

The therapeutic armamentarium of oral diabetic agents has expanded its horizon from sulfonylureas in 1995 the only drug available for treating type 2 diabetes mellitus at that time to eleven classes of oral diabetes agents at present ranging from biguanides, thiazolidinediones, dipeptidyl peptidase-4 (DPP-4) inhibitors, alpha glucosidase inhibitors and sodium-glucose cotransporter (SGLT2) inhibitors. Despite the availability of so many options glycemic control remains suboptimal posing a real challenge for the clinicians to choose the best amongst them in treating type 2 diabetes mellitus.