An Intramolecular Interaction between Src Homology 3 Domain and Guanylate Kinase-Like Domain Required for Channel Clustering by Postsynaptic Density-95/SAP90

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Population

PSD-95/SAP90 family of membrane-associated guanylate kinase (MAGUK) proteins

Comparison

Mutations disrupting the intramolecular SH3-GK… vs Wild-type PSD-95/SAP90 proteins

Design

Preclinical

Authors

Discussion

SH3-GK disruption selectively impairs Kv1.4 clustering in models; leaves open in vivo roles in neuronal or cardiac excitability.

Population

PSD-95/SAP90 family of membrane-associated guanylate kinase (MAGUK) proteins

Intervention

Mutations disrupting the intramolecular SH3-GK interaction

Comparator

Wild-type PSD-95/SAP90 proteins

Outcome

Protein-protein interaction between SH3 and GK domains, and clustering of Kv1.4 by PSD-95surrogate

The intramolecular SH3-GK interaction in PSD-95 is required for its clustering activity of Kv1.4 channels.

Shin et al. (2000) studied this question.

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