Physiology of Gonadotropin-Releasing Hormone (Gnrh): Beyond the Control of Reproductive Functions

This is the authors' abstract. We don't add key points for this paper.

GnRH is the hypothalamic main regulator of the hypothalamic-pituitary-gonadal reproductive axis, but it was found to exert additional functions due to the wide distribution of its receptors both in central nervous system (from cortex to spinal cord) and in peripheral organs and tissues. The possible activity of GnRH/GnRHR system at the level of the hippocampus has raised the interest on the effects of the decapeptide and its analogues on neurogenesis and neuronal functions. Recently, it has been observed that GnRH is decreased in mouse hypothalamic ageing and that restoring normal GnRH levels may attenuate brain and systemic aging processes.