January 1, 2001Journal of Vascular Research

Protons Inhibit the BKCa Channel of Rat Small Artery Smooth Muscle Cells

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Population

Smooth muscle cells freshly isolated from rat tail small arteries

Comparison

Alteration of intracellular proton concentration vs Different intracellular pH levels

Design

Preclinical

Authors

RSRudolf SchubertUniversity of Augsburg UKUlrike KrienBulgarian Academy of Sciences HGHristo GagovSofia University "St. Kliment Ohridski"

Discussion

Member takes

Implication

Proton-BKCa inhibition may influence vascular tone in acidosis; leaves open human relevance and requires further study.

Structured PICO

Population

Smooth muscle cells freshly isolated from rat tail small arteries

Intervention

Alteration of intracellular proton concentration (pHi ranging from 7.0 to 7.8)

Comparator

Different intracellular pH levels (e.g., pHi 7.4 as baseline)

Outcome

BKCa channel activity, single-channel conductance, voltage dependence of activation, and current amplitudesurrogate

Intracellular protons inhibit BKCa channels in rat small artery smooth muscle cells, reducing current amplitude without affecting single-channel conductance.

Cite This Study

Schubert et al. (2001) studied this question.

synapsesocial.com/papers/6a6fe4aa35aa2c282ce134c1 https://doi.org/10.1159/000051027

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Protons Inhibit the BKCa Channel of Rat Small Artery Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protons Inhibit the BKCa Channel of Rat Small Artery Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider