Why the study?
The study was conducted to identify medications with potentially beneficial effects on decreasing mortality in patients with acute kidney injury while in the intensive care unit.
Does ondansetron reduce ICU mortality in patients with acute kidney injury?
Does ondansetron reduce ICU mortality in patients with acute kidney injury?
Ondansetron use is associated with reduced ICU mortality in patients with acute kidney injury, potentially mediated through the NF-KB and JAK-STAT pathways.
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Observational associations in AKI warrant prospective validation; should not change practice.
Guo et al. (2021) studied this question.
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