Why the study?
Proton beam therapy causing radiation-induced pericarditis is not a well-known cause of pericarditis.
Proton beam therapy can cause acute pericarditis, highlighting the need for clinical vigilance for radiation-induced cardiotoxicity even with targeted radiation techniques.
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Proton beam therapy may cause acute pericarditis; this Level 5 case leaves the association hypothesis-generating pending larger studies.
Acute pericarditis is caused by the inflammation of the pericardium which can result in an effusion around the heart. Proton beam therapy causing radiation-induced pericarditis is not a well-known cause of pericarditis. We present a case of a patient with Li-Fraumeni Syndrome who developed acute onset pericarditis, presumed to be secondary to proton beam therapy.
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Gupta et al. (2022) studied this question.
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