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March 6, 2015Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Nonalcoholic Fatty Liver Disease and Vascular Function

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Why the study?

Is nonalcoholic fatty liver disease associated with impaired vascular function independent of established cardiometabolic risk factors in patients without overt cardiovascular disease?

Population

2284 Framingham Heart Study participants without overt cardiovascular disease, mean age 52±12 years, 51.4%…

Comparison

Nonalcoholic fatty liver disease assessed by… vs Participants without NAFLD or with lower liver fat

Design

Cross-sectional

Authors

MLMichelle T. LongNWNa WangMLMartin G. Larson

Discussion

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Overview

Supports NAFLD-microvascular dysfunction link beyond adiposity; hypothesis-generating for causality and cardiovascular risk.

Structured PICO

Is nonalcoholic fatty liver disease associated with impaired vascular function independent of established cardiometabolic risk factors in patients without overt cardiovascular disease?

P
Population
2284 Framingham Heart Study participants without overt cardiovascular disease, mean age 52±12 years, 51.4% women.
I
Intervention
Nonalcoholic fatty liver disease (NAFLD) assessed by liver fat attenuation on computed tomography
C
Comparator
Participants without NAFLD or with lower liver fat
O
Outcome
Vascular function measures including flow-mediated dilation, peripheral arterial tonometry ratio, carotid-femoral pulse wave velocity, and mean arterial pressuresurrogate

NAFLD is associated with microvascular dysfunction (reduced peripheral arterial tonometry response) independent of established cardiometabolic risk factors, including visceral adiposity.

Cite This Study

Long et al. (2015) studied this question.

synapsesocial.com/papers/6a6fe84ff44fa9f079dd66ffhttps://doi.org/10.1161/atvbaha.114.305200
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