Why the study?
MicroRNA-125b regulates inflammatory responses in cardiovascular diseases, but its role in modulating endothelial progenitor cell function in ischemic hearts remained unclear.
Does miR-125b overexpression improve endothelial progenitor cell function and cardiac recovery in a myocardial infarction model?
Population
Cultured endothelial progenitor cells and a mouse myocardial infarction model
Comparison
Transfection with miR-125b mimic vs negative control mimic
Design
In vitro cell study and in vivo preclinical animal model
Authors
Loading...
miR-125b may modulate EPC function in TNF-α inflammation; leaves open therapeutic targeting in ischemic heart disease.
Does miR-125b overexpression improve endothelial progenitor cell function and cardiac recovery in a myocardial infarction model?
Upregulation of miR-125b protects endothelial progenitor cells against inflammatory injury and improves their ability to mediate neovascularization and cardiac repair after myocardial infarction.
Yang et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: