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January 28, 2020Cardiovascular Research

Promise of autologous CD34+ stem/progenitor cell therapy for treatment of cardiovascular disease

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Key result

Autologous CD34+ cell therapy has shown potential safety and efficacy in various cardiovascular diseases, including acute myocardial infarction, heart failure, and refractory angina.

Why the study?

Autologous CD34+ cells have shown regenerative and angiogenic potential in ischaemia, prompting review of trials evaluating their safety and therapeutic potential across cardiovascular diseases.

Does autologous CD34+ stem/progenitor cell therapy improve outcomes in patients with cardiovascular disease?

Design

Review

Authors

MPMegha PrasadMCMichel CorbanTHTimothy D. Henry

Discussion

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Overview

Supports expanded regenerative options in refractory CV disease; extends late-phase trial evidence across multiple indications.

Structured PICO

Does autologous CD34+ stem/progenitor cell therapy improve outcomes in patients with cardiovascular disease?

P
Population
Patients with cardiovascular disease, including no-options refractory angina, acute myocardial infarction (AMI), heart failure, and coronary microvascular disease
I
Intervention
Autologous CD34+ stem/progenitor cell therapy

Autologous CD34+ stem cell therapy shows promise as a safe and potentially effective regenerative treatment for refractory angina, acute myocardial infarction, and heart failure.

Cite This Study

Prasad et al. (2020) conducted a review in Cardiovascular disease (refractory angina, acute myocardial infarction, heart failure). Autologous CD34+ stem/progenitor cell therapy was evaluated. Autologous CD34+ cell therapy has shown potential safety and efficacy in various cardiovascular diseases, including acute myocardial infarction, heart failure, and refractory angina.

synapsesocial.com/papers/6a71d43335aa2c282ce2f367https://doi.org/10.1093/cvr/cvaa027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD34+ Stem Cell Therapy in Nonischemic Dilated Cardiomyopathy Patients2013 · 18 citations
  2. 2Human CD34 <sup>+</sup> Cells in Experimental Myocardial Infarction2010 · 88 citations
  3. 3Multilineage contribution of CD34+ cells in cardiac remodeling after ischemia/reperfusion injury2023 · 9 citations
  4. 4Autologous CD34+ cell therapy improves exercise capacity, angina frequency and reduces mortality in no-option refractory angina: a patient-level pooled analysis of randomized double-blinded trials2017 · 104 citations
  5. 5CAR-CD34 (+) hematopoietic stem/progenitor cells produced in vivo protect against thoracic aortic aneurysm and dissection2026