Key result
Elevated serum uric acid is a marker for decreased renal function and likely has a causal role in hypertension and vascular disease, though its role in CKD prevention requires clinical trials.
PURPOSE OF REVIEW: To assess the current data suggesting that uric acid-lowering therapy may be useful in the prevention or mitigation of chronic kidney disease (CKD). RECENT FINDINGS: Eleven observational studies assessing the potential role of serum uric acid in the prevalence and progression of CKD have been published in the past 2 years. Seven suggest an association, whereas four do not. Recent experimental models and clinical trials have mechanistically linked serum uric acid and hypertension, an established risk factor for CKD. SUMMARY: Elevated serum uric acid is a marker for decreased renal function, may have a mechanistic role in the incidence and progression of renal functional decline and likely has a causal role in hypertension and vascular disease. Clinical trials are needed to determine whether uric acid-lowering therapy will be effective in preventing CKD.
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Daniel I. Feig (2009) conducted a review in Chronic kidney disease (CKD). Elevated serum uric acid was evaluated. Elevated serum uric acid is a marker for decreased renal function and likely has a causal role in hypertension and vascular disease, though its role in CKD prevention requires clinical trials.
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