The effect of changes in effector ligand activity on the oxygen affinity of human whole blood was calculated for protons, carbon dioxide, and 2,3-diphosphoglycerate (DPG) at various concentrations of these ligands. The data were used to obtain, from experimentally obtained oxygen dissociation curves of blood from apparently healthy subjects, the standard oxygen dissociation curve (pH = 7.40, Pco2 = 40 mm Hg, DPG = 5.0 mmol/l, and HbCO = 1.0%) of normal human blood.
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Arturson et al. (1974) studied this question.
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