Summary. 1. Rebreathing experiments similar to the procedure in Sjö strand's CO method for determination of blood volume were performed. 2. During these experiments blood samples were drawn and analyzed for their CO content with a method which permitted great accuracy even at low COHb values. 3. The results were used for the calculation of a factor L, which is an expression of the relative affinities of CO and O 2 for hemoglobin during the formation of an additional amount of COHb. 4. The results indicate that COHb determinations by analyses of the alveolar air give unreliable results. Determinations of total hemoglobin would occasionally give aberrant results. However, in 5 cases out of 7 the factor L fell within a very narrow range, 219–229. Further investigations will be necessary to explain the reasons for the deviation of the factor L in the other two experiments.
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H Dahlström (1955) studied this question.