Predicting diffusive alveolar oxygen transfer from carbon monoxide-diffusing capacity in exercising foxhounds

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Population

43 adult dogs (foxhounds), with normal lungs or reduced lung capacity following lung resection

Comparison

Rebreathing technique to measure DL and… vs Multiple inert-gas elimination technique to…

Design

Preclinical

Authors

Discussion

Supports Roughton-Forster equation in canine exercise; leaves open translation to human diffusive capacity.

Population

43 adult dogs (foxhounds), with normal lungs or reduced lung capacity following lung resection

Intervention

Rebreathing (RB) technique to measure DL(CO) and pulmonary blood flow, converted to DL(O2)(RB)

Comparator

Multiple inert-gas elimination technique (MIGET) to derive DL(O2)(MIGET)

Outcome

Correlation and mean difference between DL(O2)(RB) and DL(O2)(MIGET)surrogate

The Roughton-Forster equation adequately predicts diffusive O2 transfer from rest to heavy exercise in canines using DL(CO).

Hsia et al. (2008) studied this question.

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