Key result
Structural analysis clarifies CETP lipid transfer mechanisms between HDL and LDL in reverse cholesterol transport.
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Review highlights structural mechanisms of cholesteryl ester-transfer protein in lipid transfer, indicating potential strategies for treating atherosclerosis.
CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.
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Hall et al. (2011) conducted a review in Atherosclerosis. Cholesteryl ester-transfer protein (CETP) was evaluated. Structural and biophysical analysis of CETP provides insights into CETP-mediated lipid transfer between HDL and LDL, highlighting its critical role in the reverse cholesterol transfer pathway.
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