Why the study?
Does long-term therapeutic enoxaparin cause abnormal drug accumulation and clinical bleeding in patients with mild renal insufficiency?
Population
2 patients with venous thromboembolism and mild renal insufficiency but normal serum creatinine
Design
Case_series
Follow-up
several months
Authors
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Potential bleeding risk with long-term enoxaparin in mild renal impairment despite normal creatinine; case reports leave open need for anti-Xa monitoring.
Does long-term therapeutic enoxaparin cause abnormal drug accumulation and clinical bleeding in patients with mild renal insufficiency?
Patients receiving therapeutic enoxaparin for over 4 weeks with mild renal insufficiency may require laboratory monitoring to prevent drug accumulation and bleeding.
Busby et al. (2001) studied this question.
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