What question did this study set out to answer?

To describe and evaluate a noninvasive ultrasound method for measuring time-dependent wall shear rate and shear stress in the common carotid artery in vivo across different age cohorts.

July 1, 1995Hypertension

Noninvasive Determination of Shear-Rate Distribution Across the Arterial Lumen

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Why the study?

Does age affect the mean wall shear rate in the common carotid artery of healthy volunteers?

Population

14 presumed healthy volunteers in two age categories

Comparison

Ultrasound techniques to assess transcutaneously… vs Comparison between young and old age groups

Design

Cross-sectional

Authors

AHArnold P.G. HoeksCardiac Imaging SSSteven K. SamijoZuyderland Medisch Centrum PBPeter J. BrandsInnovation (Latvia)

Discussion

Member takes

Implication

Mean carotid shear stress is preserved across ages in healthy adults; leaves open relevance to vascular aging or clinical risk.

Key Points

To describe and evaluate a noninvasive ultrasound method for measuring time-dependent wall shear rate and shear stress in the common carotid artery in vivo across different age cohorts.
Used transcutaneous ultrasound to assess dynamic wall shear rate in the common carotid artery in vivo.
Evaluated healthy volunteers divided into a young age cohort (20 to 30 years old, n = 8) and an older age cohort (60 to 70 years old, n = 6).
Calculated shear stress assuming a blood viscosity of 3.5 mPa·s and compared results with conventional volume-flow-to-caliber estimates.
Peak shear rate was markedly higher in the young cohort compared with the older cohort.
Mean shear rate averaged over the cardiac cycle was 210 s⁻¹ in both age groups.
Estimated mean shear stress was approximately 0.7 Pa, which is a factor of two lower than the 1.5 Pa derived from volume flow and arterial caliber.

Structured PICO

Does age affect the mean wall shear rate in the common carotid artery of healthy volunteers?

Population

14 presumed healthy volunteers in two age categories (young age group, 20 to 30 years old, n = 8; old age group, 60 to 70 years old, n = 6)

Intervention

Ultrasound techniques to assess transcutaneously the time-dependent wall shear rate in vivo in the common carotid artery

Comparator

Comparison between young (20-30 years) and old (60-70 years) age groups

Outcome

Time-dependent wall shear rate and estimated shear stresssurrogate

Mean shear rate and shear stress in the common carotid artery are maintained at a constant value regardless of age, despite differences in peak shear rate.

Cite This Study

Hoeks et al. (1995) studied this question.

synapsesocial.com/papers/6a6fecffaf0c21e93927dcd8 https://doi.org/10.1161/01.hyp.26.1.26

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Noninvasive Determination of Shear-Rate Distribution Across the Arterial Lumen

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Noninvasive Determination of Shear-Rate Distribution Across the Arterial Lumen

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider