What question did this study set out to answer?

To characterize the sequential fluctuations in circulating plasma proteins and trace minerals during the first 24 hours following surgical incision.

August 1, 1984Journal of Clinical PathologyOpen Access

Early plasma protein and mineral changes after surgery: a two stage process.

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Authors

MMM A MyersUniversity of Toledo Medical Center AFA. FleckUniversity of London BSBarry SampsonCharing Cross Hospital

Discussion

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Implication

Observational study reveals two-stage plasma protein and trace mineral changes after hysterectomy, indicating early microvascular permeability followed by mediated acute-phase responses.

Key Points

To characterize the sequential fluctuations in circulating plasma proteins and trace minerals during the first 24 hours following surgical incision.
Measured serial plasma concentrations of albumin, transferrin, alpha 1-acid glycoprotein, C-reactive protein, fibrinogen, copper, iron, and zinc.
Collected sequential blood samples up to 24 hours following skin incision in patients undergoing hysterectomy.
Plasma concentrations of all proteins and minerals (albumin, transferrin, copper, iron, zinc, and acute-phase reactants) fell significantly between 2 and 4 hours post-incision.
Acute-phase proteins (alpha 1-acid glycoprotein, C-reactive protein, and fibrinogen) began increasing only after 6 hours, while iron and zinc ratios to their binding proteins dropped at 4 to 6 hours and stayed depressed through 24 hours.

Cite This Study

Myers et al. (1984) studied this question.

synapsesocial.com/papers/6a6fedb078a11c550e09b558 https://doi.org/10.1136/jcp.37.8.862

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August 1, 1984Journal of Clinical PathologyOpen Access

Early plasma protein and mineral changes after surgery: a two stage process.

View Full Paper

Ask AI

Bookmark

Authors

MMM A MyersUniversity of Toledo Medical Center AFA. FleckUniversity of London BSBarry SampsonCharing Cross Hospital

Discussion

Member takes

Implication

Observational study reveals two-stage plasma protein and trace mineral changes after hysterectomy, indicating early microvascular permeability followed by mediated acute-phase responses.

Key Points

To characterize the sequential fluctuations in circulating plasma proteins and trace minerals during the first 24 hours following surgical incision.
Measured serial plasma concentrations of albumin, transferrin, alpha 1-acid glycoprotein, C-reactive protein, fibrinogen, copper, iron, and zinc.
Collected sequential blood samples up to 24 hours following skin incision in patients undergoing hysterectomy.
Plasma concentrations of all proteins and minerals (albumin, transferrin, copper, iron, zinc, and acute-phase reactants) fell significantly between 2 and 4 hours post-incision.
Acute-phase proteins (alpha 1-acid glycoprotein, C-reactive protein, and fibrinogen) began increasing only after 6 hours, while iron and zinc ratios to their binding proteins dropped at 4 to 6 hours and stayed depressed through 24 hours.

Cite This Study

Myers et al. (1984) studied this question.

synapsesocial.com/papers/6a6fedb078a11c550e09b558 https://doi.org/10.1136/jcp.37.8.862

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