Influence of Cortisol Analogs on Secondary Hemostasis Indices in Cyprinus carpio Carp

Data on the dynamics of the carp (Cyprinus carpio L.) coagulogram, as well as stress markers under the influence of synthetic analogs of short- and long-acting cortisol within 21 days, have been obtained. A comparative analysis of changes in these indices in the experimental groups and in intact fish has been carried out. It is detected that the clotting ability of the blood increased during the experiment in all animals involved in the experiment due to some plasma factors, although the curve of these changes in groups differs. An acceleration of activated partial thromboplastin time, prothrombin time, and an increase in the concentration of fibrinogen in the fish blood are noted. At the same time, the nature of changes in the content of soluble fibrin monomer complexes, as well as antithrombin III, indicates the development of hypocoagulation processes in fish of certain groups. The cortisol response in hormone-treated animals is contradictory. Assumptions are made about the reasons for the dynamics of indices noted not only in experimental, but also in control fish. Statistical analysis has revealed the correlations between cortisol and individual parameters of hemostasis.