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Does simultaneously monitoring both T1 and T2 signal intensities on a bolus injection of Gd-DTPA distinguish infarcted myocardium in ex vivo pig hearts?
Does simultaneously monitoring both T1 and T2 signal intensities on a bolus injection of Gd-DTPA distinguish infarcted myocardium in ex vivo pig hearts?
Simultaneous monitoring of T1 and T2 signal intensities during Gd-DTPA bolus injection can differentiate normal, reperfused infarcted, and low-reflow infarcted myocardium in an ex vivo model.
PURPOSE: To determine whether injured myocardium may be identified by simultaneously monitoring contrast-induced T(1) and T(2)* signal intensity time-course changes with an interleaved T(1)-T(2)* imaging sequence. MATERIALS AND METHODS: Gadolinium-diethylene triamine pentaacetic acid (0.05 mmol/ kg) was injected as a bolus into ex vivo pig hearts, and simultaneous T(1) and T(2)* time-courses were obtained during the first pass. RESULTS: Observing contrast-enhanced R(1) or R(2)* rates (1/T(1) or 1/T(2)* times, respectively) early after contrast injection did not fully differentiate viable from nonviable myocardium. T(2)* recovery at maximal T(1) signal intensity, measured using simultaneous T(1) and T(2)* imaging, displayed a significantly different percentage recovery (P < 0.05) among normal (30.5 +/- 2.4% of baseline value), reperfused infarcted (63 +/- 7.2%), and low-reflow infarcted (90 +/- 2.8%) myocardium. CONCLUSION: Simultaneously monitoring both T(1) and T(2)* signal intensities may help in the assessment of myocardial injury.
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Mark et al. (2002) studied this question.
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