What question did this study set out to answer?

This study aims to evaluate mechanisms behind altered contrast enhancement in MRI after myocardial infarction and relate these patterns to myocardial perfusion and viability.

December 15, 1996Circulation

Myocardial Gd-DTPA Kinetics Determine MRI Contrast Enhancement and Reflect the Extent and Severity of Myocardial Injury After Acute Reperfused Infarction

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Authors

RKRaymond J. KimCardiac Imaging ECEnn-Ling ChenDuke Medical Center JLJoa ̃o A.C. LimaJohns Hopkins Hospital

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Implication

Randomized trial evaluates contrast enhancement and myocardial injury severity using MRI in rabbits, indicating important diagnostic pathways.

Key Points

This study aims to evaluate mechanisms behind altered contrast enhancement in MRI after myocardial infarction and relate these patterns to myocardial perfusion and viability.
Thirteen rabbits experienced coronary artery occlusion followed by reperfusion and isolated perfusion with cardioplegic solution.
Continuous acquisition of T1-weighted spin-echo images during changes in perfusate Gd-DTPA concentration was performed.
Regional blood flow was measured using radioactive microspheres.
Significant differences in Gd-DTPA wash-in (P < .001) and washout time constants (P < .001) were observed across regions: normal myocardium, infarct rim, and infarct core.
Microsphere blood flow in infarct regions reflected microvascular damage severity, correlating (r = .86, P < .001) with washout time constants.
The area of abnormal time constants closely matched the infarct size determined by triphenyltetrazolium chloride (r = .94, P < .001).

Cite This Study

Kim et al. (1996) studied this question.

synapsesocial.com/papers/69f6910be405cc4465bc2a3b https://doi.org/10.1161/01.cir.94.12.3318

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Implication

Randomized trial evaluates contrast enhancement and myocardial injury severity using MRI in rabbits, indicating important diagnostic pathways.

Myocardial Gd-DTPA Kinetics Determine MRI Contrast Enhancement and Reflect the Extent and Severity of Myocardial Injury After Acute Reperfused Infarction

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Cite This Study

Myocardial Gd-DTPA Kinetics Determine MRI Contrast Enhancement and Reflect the Extent and Severity of Myocardial Injury After Acute Reperfused Infarction

Discussion

Member takes

Implication

Key Points

Cite This Study

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