What question did this study set out to answer?

Characterize susceptibility-induced MRI contrast effects on spin echo T2-weighted imaging in reperfused myocardial infarction, evaluating whether tissue compartmentalization is lost in damaged myocardium.

January 1, 1994Magnetic Resonance in Medicine

Reperfused myocardial infarctions on T1‐ and susceptibility‐enhanced MRI: Evidence for loss of compartmentalization of contrast media

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Authors

MSMaythem SaeedUniversity of California, San Francisco MWMichael F. WendlandQB3 TMTakayuki MasuiSeirei Hamamatsu General Hospital

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Implication

Preclinical study reveals altered contrast distribution during susceptibility-enhanced MRI in rat myocardial infarction, indicating loss of cellular compartmentalization in necrotic tissue.

Key Points

Characterize susceptibility-induced MRI contrast effects on spin echo T2-weighted imaging in reperfused myocardial infarction, evaluating whether tissue compartmentalization is lost in damaged myocardium.
Subjected nine rats to 2 hours of left coronary artery occlusion followed by 3 ± 0.5 hours of reperfusion.
Acquired midventricle baseline T1-weighted (TR/TE = 300/20) and T2-weighted (TR/TE = 1500/60) spin echo MR images.
Performed sequential contrast-enhanced imaging using Gd-DTPA-BMA (0.2 mmol/kg) to verify reperfusion and Dy-DTPA-BMA (1.0 mmol/kg) to assess susceptibility contrast, comparing MR findings with postmortem staining.
Infarction sizes measured by unenhanced T2-weighted images (33 ± 5%) and gadolinium-enhanced T1-weighted images (36 ± 5%) strongly correlated with postmortem staining (30 ± 6%, r > 0.9).
Dysprosium-enhanced T2-weighted images depicted a significantly smaller injury zone (20 ± 5%, P < 0.05) with weak correlation to other measurements (r < 0.75), indicating homogeneous agent distribution across necrotic compartments that prevents spin echo phase loss.

Cite This Study

Saeed et al. (1994) studied this question.

synapsesocial.com/papers/6a0ea88253f874f2b2229bd2 https://doi.org/10.1002/mrm.1910310105

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Implication

Preclinical study reveals altered contrast distribution during susceptibility-enhanced MRI in rat myocardial infarction, indicating loss of cellular compartmentalization in necrotic tissue.

Reperfused myocardial infarctions on T1‐ and susceptibility‐enhanced MRI: Evidence for loss of compartmentalization of contrast media

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Implication

Key Points

Cite This Study

Reperfused myocardial infarctions on T1‐ and susceptibility‐enhanced MRI: Evidence for loss of compartmentalization of contrast media

Discussion

Member takes

Implication

Key Points

Cite This Study

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