Why the study?
Controversy persists over the pathophysiology underlying Brugada syndrome regarding channelopathy versus cardiomyopathy and repolarization versus depolarization abnormalities.
Design
Review
Authors
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BrS management unchanged by ongoing debate; leaves open whether channelopathy or cardiomyopathy predominates.
This review proposes a unifying pathophysiological theory for Brugada syndrome as a disease of reduced right ventricular outflow tract conduction reserve.
Behr et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: