Why the study?
Does regular physical activity reduce arterial stiffness differently based on ER-alpha genotype in healthy postmenopausal women?
Does regular physical activity reduce arterial stiffness differently based on ER-alpha genotype in healthy postmenopausal women?
The ER-alpha -401T/C polymorphism modulates the beneficial effect of regular physical activity on arterial stiffness in postmenopausal women, with the TC+CC genotype showing improvement while the TT genotype does not.
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Supports genotype-stratified activity effects on stiffness; hypothesis-generating and requires prospective validation before clinical use.
Hayashi et al. (2008) studied this question.
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