What question did this study set out to answer?

To significantly expand and standardize the Drosophila Genome Nexus to support large-scale population genomic studies and multi-population allele frequency comparisons.

September 29, 2016Molecular Biology and EvolutionOpen Access

A Thousand Fly Genomes: An Expanded Drosophila Genome Nexus

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Authors

JLJustin LackNational Institutes of Health JLJeremy D. LangeGerman Cancer Research Center ATAlison D. TangFreenome (United States)

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Implication

Genomic resource update reveals 1,121 standardized wild-derived genomes in Drosophila melanogaster, highlighting new opportunities to study population variation and evolutionary divergence.

Key Points

To significantly expand and standardize the Drosophila Genome Nexus to support large-scale population genomic studies and multi-population allele frequency comparisons.
Aligned wild-derived genomes using a standardized reference alignment pipeline involving two rounds of mapping.
Annotated genomic regions for residual heterozygosity, identity-by-descent, and recent population admixture to facilitate user filtering.
Integrated 305 previously unpublished genomes from Egypt, Ethiopia, France, and South Africa, alongside 193 genomes from published datasets and a reference-aligned Drosophila simulans genome.
Expanded the Drosophila Genome Nexus database to a total of 1,121 wild-derived Drosophila melanogaster genomes.
Provided an aligned Drosophila simulans genome to enable cross-species divergence analyses alongside within-species variation data.

Cite This Study

Lack et al. (2016) studied this question.

synapsesocial.com/papers/6a6ff1bb439bab0cabc2f622 https://doi.org/10.1093/molbev/msw195

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Implication

Genomic resource update reveals 1,121 standardized wild-derived genomes in Drosophila melanogaster, highlighting new opportunities to study population variation and evolutionary divergence.

A Thousand Fly Genomes: An Expanded Drosophila Genome Nexus

Discussion

Member takes

Implication

Key Points

Cite This Study

A Thousand Fly Genomes: An Expanded Drosophila Genome Nexus

Discussion

Member takes

Implication

Key Points

Cite This Study

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