Why the study?
Does chronic AC magnetic field exposure alter contraction and relaxation of thoracic aorta rings in healthy and diabetic rats?
Does chronic AC magnetic field exposure alter contraction and relaxation of thoracic aorta rings in healthy and diabetic rats?
Chronic AC magnetic field exposure alters vascular reactivity by attenuating contraction and enhancing endothelium-dependent relaxation in isolated rat aortas.
No clinical implications for vascular disease; leaves open translation of magnetic field effects from diabetic rat models.
The aim of in this study was to determine the effect of chronic alternating current (AC) magnetic field on the contraction and relaxation parameters of isolated thoracic aorta rings in healthy and diabetic rats. Sixty rats (Wistar albino spp) weighing between 250-300 g were used. The rats were divided into four groups: 1-Control (C), 2- control + magnetic field (C+MA), 3- experimental diabetic (DIA), 4- experimental diabetic and magnetic field (DIA+MA). Magnetic fields of 5 mT intensity and 50 Hz frequency oriented in the north-south direction was applied to the C+MA and DIA+MA groups for 2 hours each day for one month, after which rats were killed by decapitation and the thoracic aorta dissected. This showed attenuated contraction responses to phenylephrine (PE) and elevated relaxation responses to acetylcholine (ACh) of the thoracic aorta rings of rats in the C+MA and DIA+MA groups compared to group C but no changes in the relaxation responses to sodium nitroprruside (SNP) of thoracic aorta rings relative to group C and DIA. The weights of rats in DIA+MA or C+MA groups compared to the DIA and C groups decreased.
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Öcal et al. (2004) studied this question.
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